The Block of DNA Polymerase δ Strand Displacement Activity by an Abasic Site Can Be Rescued by the Concerted Action of DNA Polymerase β and Flap Endonuclease 1

Abasic (AP) sites are very frequent and dangerous DNA lesions. Their ability to block the advancement of a replication fork has been always viewed as a consequence of their inhibitory effect on the DNA synthetic activity of replicative DNA polymerases (DNA pols). Here we show that AP sites can also...

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Библиографические подробности
Главные авторы: Maga, Giovanni, van Loon, Barbara, Crespan, Emmanuele, Villani, Giuseppe, Hübscher, Ulrich
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2009
Предметы:
DNA: Replication, Repair, Recombination, and Chromosome Dynamics
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2682875/
https://ncbi.nlm.nih.gov/pubmed/19329428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M900759200
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