Okazaki fragment processing: Modulation of the strand displacement activity of DNA polymerase δ by the concerted action of replication protein A, proliferating cell nuclear antigen, and flap endonuclease-1

DNA polymerase (pol) δ is essential for both leading and lagging strand DNA synthesis during chromosomal replication in eukaryotes. Pol δ has been implicated in the Okazaki fragment maturation process for the extension of the newly synthesized fragment and for the displacement of the RNA/DNA segment...

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Detalhes bibliográficos
Main Authors: Maga, Giovanni, Villani, Giuseppe, Tillement, Vanessa, Stucki, Manuel, Locatelli, Giada A., Frouin, Isabelle, Spadari, Silvio, Hübscher, Ulrich
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2001
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC64676/
https://ncbi.nlm.nih.gov/pubmed/11724925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.251193198
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