Molecular Basis of Catalytic Chamber-assisted Unfolding and Cleavage of Human Insulin by Human Insulin-degrading Enzyme

Insulin is a hormone vital for glucose homeostasis, and insulin-degrading enzyme (IDE) plays a key role in its clearance. IDE exhibits a remarkable specificity to degrade insulin without breaking the disulfide bonds that hold the insulin A and B chains together. Using Fourier transform ion cyclotron...

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Hlavní autoři: Manolopoulou, Marika, Guo, Qing, Malito, Enrico, Schilling, Alexander B., Tang, Wei-Jen
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2009
Témata:
Enzyme Catalysis and Regulation
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2682866/
https://ncbi.nlm.nih.gov/pubmed/19321446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M900068200
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