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Regulatory Elements within the Prodomain of Falcipain-2, a Cysteine Protease of the Malaria Parasite Plasmodium falciparum

Falcipain-2, a papain family cysteine protease of the malaria parasite Plasmodium falciparum, plays a key role in parasite hydrolysis of hemoglobin and is a potential chemotherapeutic target. As with many proteases, falcipain-2 is synthesized as a zymogen, and the prodomain inhibits activity of the...

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Главные авторы: Pandey, Kailash C., Barkan, David T., Sali, Andrej, Rosenthal, Philip J.
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2009
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2682653/
https://ncbi.nlm.nih.gov/pubmed/19479029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0005694
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