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The Plasmodium falciparum cysteine protease falcipain-2 captures its substrate, hemoglobin, via a unique motif
Falcipain-2 (FP2) is a papain family cysteine protease and important hemoglobinase of erythrocytic Plasmodium falciparum parasites. Inhibitors of FP2 block hemoglobin hydrolysis and parasite development, suggesting that this enzyme is a promising target for antimalarial chemotherapy. FP2 and related...
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| Hauptverfasser: | , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2005
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1166610/ https://ncbi.nlm.nih.gov/pubmed/15964982 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0502368102 |
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