Hemoglobin Cleavage Site-Specificity of the Plasmodium falciparum Cysteine Proteases Falcipain-2 and Falcipain-3

The Plasmodium falciparum cysteine proteases falcipain-2 and falcipain-3 degrade host hemoglobin to provide free amino acids for parasite protein synthesis. Hemoglobin hydrolysis has been described as an ordered process initiated by aspartic proteases, but cysteine protease inhibitors completely blo...

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Main Authors: Subramanian, Shoba, Hardt, Markus, Choe, Youngchool, Niles, Richard K., Johansen, Eric B., Legac, Jennifer, Gut, Jiri, Kerr, Iain D., Craik, Charles S., Rosenthal, Philip J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2663817/
https://ncbi.nlm.nih.gov/pubmed/19357776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0005156
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