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The Plasmodium falciparum cysteine protease falcipain-2 captures its substrate, hemoglobin, via a unique motif

Falcipain-2 (FP2) is a papain family cysteine protease and important hemoglobinase of erythrocytic Plasmodium falciparum parasites. Inhibitors of FP2 block hemoglobin hydrolysis and parasite development, suggesting that this enzyme is a promising target for antimalarial chemotherapy. FP2 and related...

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Main Authors: Pandey, Kailash C., Wang, Stephanie X., Sijwali, Puran S., Lau, Anthony L., McKerrow, James H., Rosenthal, Philip J.
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2005
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1166610/
https://ncbi.nlm.nih.gov/pubmed/15964982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0502368102
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