Autophagosome-Independent Essential Function for the Autophagy Protein Atg5 in Cellular Immunity to Intracellular Pathogens

The physiologic importance of autophagy proteins for control of mammalian bacterial and parasitic infection in vivo is unknown. Using mice with granulocyte- and macrophage-specific deletion of the essential autophagy protein Atg5, we show that Atg5 is required for in vivo resistance to the intracell...

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Bibliografiske detaljer
Main Authors: Zhao, Zijiang, Fux, Blima, Goodwin, Megan, Dunay, Ildiko R., Strong, David, Miller, Brian C., Cadwell, Ken, Delgado, Monica A., Ponpuak, Marisa, Green, Karen G., Schmidt, Robert E., Mizushima, Noboru, Deretic, Vojo, Sibley, L. David, Virgin, Herbert W.
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier Inc. 2008
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2682425/
https://ncbi.nlm.nih.gov/pubmed/18996346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2008.10.003
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