Autophagosome-Independent Essential Function for the Autophagy Protein Atg5 in Cellular Immunity to Intracellular Pathogens

The physiologic importance of autophagy proteins for control of mammalian bacterial and parasitic infection in vivo is unknown. Using mice with granulocyte- and macrophage-specific deletion of the essential autophagy protein Atg5, we show that Atg5 is required for in vivo resistance to the intracell...

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Hlavní autoři: Zhao, Zijiang, Fux, Blima, Goodwin, Megan, Dunay, Ildiko R., Strong, David, Miller, Brian C., Cadwell, Ken, Delgado, Monica A., Ponpuak, Marisa, Green, Karen G., Schmidt, Robert E., Mizushima, Noboru, Deretic, Vojo, Sibley, L. David, Virgin, Herbert W.
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier Inc. 2008
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2682425/
https://ncbi.nlm.nih.gov/pubmed/18996346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2008.10.003
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