Enhanced Exposure of the CD4-Binding Site to Neutralizing Antibodies by Structural Design of a Membrane-Anchored Human Immunodeficiency Virus Type 1 gp120 Domain

The broadly neutralizing antibody immunoglobulin G1 (IgG1) b12 binds to a conformationally conserved surface on the outer domain of the human immunodeficiency virus type 1 (HIV-1) gp120 envelope (Env) glycoprotein. To develop outer domain proteins (ODs) that could be recognized selectively by CD4-bi...

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Main Authors: Wu, Lan, Zhou, Tongqing, Yang, Zhi-yong, Svehla, Krisha, O'Dell, Sijy, Louder, Mark K., Xu, Ling, Mascola, John R., Burton, Dennis R., Hoxie, James A., Doms, Robert W., Kwong, Peter D., Nabel, Gary J.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology (ASM) 2009
Teme:
Vaccines and Antiviral Agents
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2682083/
https://ncbi.nlm.nih.gov/pubmed/19264769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02600-08
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