Trophoblast Stem Cell Maintenance by Fibroblast Growth Factor 4 Requires MEKK4 Activation of Jun N-Terminal Kinase

Trophoblast differentiation during placentation involves an epithelial-mesenchymal transition (EMT) with loss of E-cadherin and gain of trophoblast invasiveness. Mice harboring a point mutation that renders inactive the mitogen-activated protein kinase kinase kinase MEKK4 exhibit dysregulated placen...

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Main Authors: Abell, Amy N., Granger, Deborah A., Johnson, Nancy L., Vincent-Jordan, Nicole, Dibble, Christopher F., Johnson, Gary L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2009
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2682043/
https://ncbi.nlm.nih.gov/pubmed/19289495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01391-08
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