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MEKK1 regulates calpain-dependent proteolysis of focal adhesion proteins for rear-end detachment of migrating fibroblasts

Herein, we define how MEKK1, a MAPK kinase kinase, regulates cell migration. MEKK1 is associated with actin fibers and focal adhesions, localizing MEKK1 to sites critical in the control of cell adhesion and migration. EGF-induced ERK1/2 activation and chemotaxis are inhibited in MEKK1–/– fibroblasts...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Cuevas, Bruce D., Abell, Amy N., Witowsky, James A., Yujiri, Toshiaki, Lassignal Johnson, Nancy, Kesavan, Kamala, Ware, Marti, Jones, Peter L., Weed, Scott A., DeBiasi, Roberta L., Oka, Yoshitomo, Tyler, Kenneth L., Johnson, Gary L.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: Oxford University Press 2003
Θέματα:
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC165646/
https://ncbi.nlm.nih.gov/pubmed/12839996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdg322
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