MEKK1 regulates calpain-dependent proteolysis of focal adhesion proteins for rear-end detachment of migrating fibroblasts

Herein, we define how MEKK1, a MAPK kinase kinase, regulates cell migration. MEKK1 is associated with actin fibers and focal adhesions, localizing MEKK1 to sites critical in the control of cell adhesion and migration. EGF-induced ERK1/2 activation and chemotaxis are inhibited in MEKK1–/– fibroblasts...

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Bibliographic Details
Main Authors: Cuevas, Bruce D., Abell, Amy N., Witowsky, James A., Yujiri, Toshiaki, Lassignal Johnson, Nancy, Kesavan, Kamala, Ware, Marti, Jones, Peter L., Weed, Scott A., DeBiasi, Roberta L., Oka, Yoshitomo, Tyler, Kenneth L., Johnson, Gary L.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2003
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC165646/
https://ncbi.nlm.nih.gov/pubmed/12839996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdg322
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