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Cdc42 and Rac Family GTPases Regulate Mode and Speed but Not Direction of Primary Fibroblast Migration during Platelet-Derived Growth Factor-Dependent Chemotaxis

Cdc42 and Rac family GTPases are important regulators of morphology, motility, and polarity in a variety of mammalian cell types. However, comprehensive analysis of their roles in the morphological and behavioral aspects of chemotaxis within a single experimental system is still lacking. Here we dem...

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Main Authors: Monypenny, James, Zicha, Daniel, Higashida, Chiharu, Oceguera-Yanez, Fabian, Narumiya, Shuh, Watanabe, Naoki
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology (ASM) 2009
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2682035/
https://ncbi.nlm.nih.gov/pubmed/19273601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01285-08
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