Novel S-Adenosylmethionine Decarboxylase Inhibitors for the Treatment of Human African Trypanosomiasis

Trypanosomiasis remains a significant disease across the sub-Saharan African continent, with 50,000 to 70,000 individuals infected. The utility of current therapies is limited by issues of toxicity and the need to administer compounds intravenously. We have begun a program to pursue lead optimizatio...

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Detalhes bibliográficos
Main Authors: Barker, Robert H., Liu, Hanlan, Hirth, Bradford, Celatka, Cassandra A., Fitzpatrick, Richard, Xiang, Yibin, Willert, Erin K., Phillips, Margaret A., Kaiser, Marcel, Bacchi, Cyrus J., Rodriguez, Aixa, Yarlett, Nigel, Klinger, Jeffrey D., Sybertz, Edmund
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2009
Assuntos:
Experimental Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2681509/
https://ncbi.nlm.nih.gov/pubmed/19289530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01674-08
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