Loss of Thy-1 inhibits alveolar development in the newborn mouse lung

Transforming growth factor (TGF)-β mediates hypoxia-induced inhibition of alveolar development in the newborn lung. TGF-β is regulated primarily at the level of activation of latent TGF-β. Fibroblasts expressing Thy-1 (CD90) inhibit TGF-β activation. We hypothesized that loss of Thy-1 due to hypoxia...

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Main Authors: Nicola, Teodora, Hagood, James S., James, Masheika L., MacEwen, Mark W., Williams, Timothy A., Hewitt, Matthew M., Schwiebert, Lisa, Bulger, Arlene, Oparil, Suzanne, Chen, Yiu-Fai, Ambalavanan, Namasivayam
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2009
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2681351/
https://ncbi.nlm.nih.gov/pubmed/19270178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.90603.2008
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