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Structural basis of nucleotide exchange and client binding by the novel Hsp70-cochaperone Bag2
Cochaperones are essential for Hsp70/Hsc70-mediated folding of proteins and include nucleotide exchange factors (NEF) that assist protein folding by accelerating ADP/ATP exchange on Hsp70. The cochaperone Bag2 binds misfolded Hsp70 clients and also acts as a NEF, but the molecular basis of its funct...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2680549/ https://ncbi.nlm.nih.gov/pubmed/19029896 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.1518 |
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