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A bipartite interaction between Hsp70 and CHIP regulates ubiquitination of chaperoned client proteins

The ubiquitin ligase CHIP plays an important role in cytosolic protein quality control by ubiquitinating proteins chaperoned by Hsp70/Hsc70 and Hsp90, thereby targeting such substrate proteins for degradation. We present a 2.91 Å resolution structure of the TPR domain of CHIP in complex with the α-h...

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Publicado en:Structure
Main Authors: Zhang, Huaqun, Amick, Joseph, Chakravarti, Ritu, Santarriaga, Stephanie, Schlanger, Simon, McGlone, Cameron, Dare, Michelle, Nix, Jay C., Scaglione, K. Matthew, Stuehr, Dennis J., Misra, Saurav, Page, Richard C.
Formato: Artigo
Idioma:Inglês
Publicado: 2015
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4351142/
https://ncbi.nlm.nih.gov/pubmed/25684577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2015.01.003
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