Overexpression of the Cochaperone CHIP Enhances Hsp70-Dependent Folding Activity in Mammalian Cells

CHIP is a cochaperone of Hsp70 that inhibits Hsp70-dependent refolding in vitro. However, the effect of altered expression of CHIP on the fate of unfolded proteins in mammalian cells has not been determined. Surprisingly, we found that overexpression of CHIP in fibroblasts increased the refolding of...

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Pubblicato in:	Mol Cell Biol
Autori principali:	Kampinga, Harm H., Kanon, Bart, Salomons, Florian A., Kabakov, Alexander E., Patterson, Cam
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Taylor & Francis 2003
Soggetti:	Cell Growth and Development
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC162225/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12832480/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.23.14.4948-4958.2003
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