Overexpression of the Cochaperone CHIP Enhances Hsp70-Dependent Folding Activity in Mammalian Cells

CHIP is a cochaperone of Hsp70 that inhibits Hsp70-dependent refolding in vitro. However, the effect of altered expression of CHIP on the fate of unfolded proteins in mammalian cells has not been determined. Surprisingly, we found that overexpression of CHIP in fibroblasts increased the refolding of...

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Podrobná bibliografie

Vydáno v:	Mol Cell Biol
Hlavní autoři:	Kampinga, Harm H., Kanon, Bart, Salomons, Florian A., Kabakov, Alexander E., Patterson, Cam
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Taylor & Francis 2003
Témata:	Cell Growth and Development
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC162225/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12832480/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.23.14.4948-4958.2003
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