Overexpression of the Cochaperone CHIP Enhances Hsp70-Dependent Folding Activity in Mammalian Cells

CHIP is a cochaperone of Hsp70 that inhibits Hsp70-dependent refolding in vitro. However, the effect of altered expression of CHIP on the fate of unfolded proteins in mammalian cells has not been determined. Surprisingly, we found that overexpression of CHIP in fibroblasts increased the refolding of...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Kampinga, Harm H., Kanon, Bart, Salomons, Florian A., Kabakov, Alexander E., Patterson, Cam
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Microbiology 2003
Gaiak:
Cell Growth and Development
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC162225/
https://ncbi.nlm.nih.gov/pubmed/12832480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.14.4948-4958.2003
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