Overexpression of the Cochaperone CHIP Enhances Hsp70-Dependent Folding Activity in Mammalian Cells

CHIP is a cochaperone of Hsp70 that inhibits Hsp70-dependent refolding in vitro. However, the effect of altered expression of CHIP on the fate of unfolded proteins in mammalian cells has not been determined. Surprisingly, we found that overexpression of CHIP in fibroblasts increased the refolding of...

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Detalhes bibliográficos

Publicado no:	Mol Cell Biol
Principais autores:	Kampinga, Harm H., Kanon, Bart, Salomons, Florian A., Kabakov, Alexander E., Patterson, Cam
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis 2003
Assuntos:	Cell Growth and Development
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC162225/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12832480/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.23.14.4948-4958.2003
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