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Mechanism of Vitamin D Receptor Inhibition of Cholesterol 7α-Hydroxylase Gene Transcription in Human Hepatocytes

Lithocholic acid (LCA) is a potent endogenous vitamin D receptor (VDR) ligand. In cholestasis, LCA levels increase in the liver and intestine. The objective of this study is to test the hypothesis that VDR plays a role in inhibiting cholesterol 7α-hydroxylase (CYP7A1) gene expression and bile acid s...

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Sonraí Bibleagrafaíochta
Main Authors: Han, Shuxin, Chiang, John Y. L.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Pharmacology and Experimental Therapeutics 2009
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2680517/
https://ncbi.nlm.nih.gov/pubmed/19106115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.108.025155
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