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A putative role of micro RNA in regulation of cholesterol 7α-hydroxylase expression in human hepatocytes
Cholesterol 7α-hydroxylase (CYP7A1) plays a critical role in regulation of bile acid synthesis in the liver. CYP7A1 mRNAs have very short half-lives, and bile acids destabilize CYP7A1 mRNA via the 3′-untranslated region (3′-UTR). However, the underlying mechanism of translational regulation of CYP7A...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
The American Society for Biochemistry and Molecular Biology
2010
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2903801/ https://ncbi.nlm.nih.gov/pubmed/20351063 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M004531 |
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