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A putative role of micro RNA in regulation of cholesterol 7α-hydroxylase expression in human hepatocytes

Cholesterol 7α-hydroxylase (CYP7A1) plays a critical role in regulation of bile acid synthesis in the liver. CYP7A1 mRNAs have very short half-lives, and bile acids destabilize CYP7A1 mRNA via the 3′-untranslated region (3′-UTR). However, the underlying mechanism of translational regulation of CYP7A...

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Bibliografiska uppgifter
Huvudupphovsmän: Song, Kwang-Hoon, Li, Tiangang, Owsley, Erika, Chiang, John Y. L.
Materialtyp: Artigo
Språk:Inglês
Publicerad: The American Society for Biochemistry and Molecular Biology 2010
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Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2903801/
https://ncbi.nlm.nih.gov/pubmed/20351063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M004531
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