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Preclinical transfusion-dependent humanized mouse model of β thalassemia major
A preclinical humanized mouse model of β thalassemia major or Cooley anemia (CA) was generated by targeted gene replacement of the mouse adult globin genes in embryonic stem cells. The mouse adult α and β globin genes were replaced with adult human α globin genes (α2α1) and a human fetal to adult he...
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| Main Authors: | , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
American Society of Hematology
2009
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2680376/ https://ncbi.nlm.nih.gov/pubmed/19258591 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-12-197012 |
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