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Targeted inhibition of the immunoproteasome is a potent strategy against models of multiple myeloma that overcomes resistance to conventional drugs and nonspecific proteasome inhibitors

Proteasome inhibition is a validated strategy for therapy of multiple myeloma, but this disease remains challenging as relapses are common, and often associated with increasing chemoresistance. Moreover, nonspecific proteasome inhibitors such as bortezomib can induce peripheral neuropathy and other...

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Detaylı Bibliyografya
Asıl Yazarlar: Kuhn, Deborah J., Hunsucker, Sally A., Chen, Qing, Voorhees, Peter M., Orlowski, Marian, Orlowski, Robert Z.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society of Hematology 2009
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2680370/
https://ncbi.nlm.nih.gov/pubmed/19050304
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-07-171637
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