Lymphocyte-specific TRAF3 transgenic mice have enhanced humoral responses and develop plasmacytosis, autoimmunity, inflammation, and cancer

Tumor necrosis factor (TNF) receptor–associated factor 3 (TRAF3) regulates both innate and adaptive immunity by modulating signaling by Toll-like receptors (TLR) and TNF receptors. TRAF3 was recently identified as a tumor suppressor in human multiple myeloma, suggesting a prominent role in plasma ce...

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Autors principals: Zapata, Juan M., Llobet, David, Krajewska, Maryla, Lefebvre, Sophie, Kress, Christina L., Reed, John C.
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2009
Matèries:
Immunobiology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2680366/
https://ncbi.nlm.nih.gov/pubmed/19074733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-07-165456
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