TNF receptor-associated factor (TRAF) domain and Bcl-2 cooperate to induce small B cell lymphoma/chronic lymphocytic leukemia in transgenic mice

Transgenic mice overexpressing in B lymphocytes either Bcl-2 or a TNF receptor-associated factor (TRAF)2 mutant lacking the N-terminal RING and zinc finger domains located at the N terminus of the molecule (TRAF2DN), which mimics TRAF1, developed lymphadenopathy and splenomegaly due to polyclonal B...

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Detalhes bibliográficos
Main Authors: Zapata, Juan M., Krajewska, Maryla, Morse, Herbert C., Choi, Yongwon, Reed, John C.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2004
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC534512/
https://ncbi.nlm.nih.gov/pubmed/15545599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0407541101
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