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Protection of Vascular Barrier Integrity by Activated Protein C in Murine Models Depends on Protease-Activated Receptor-1

Protease activated receptor-1 (PAR1) mediates barrier protective signaling of activated protein C (APC) in human endothelial cells in vitro and may contribute to APC’s beneficial effects in patients with severe sepsis. Mouse models are of key importance for translational research but species differe...

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Main Authors: Schuepbach, Reto A., Feistritzer, Clemens, Fernández, José A., Griffin, John H., Riewald, Matthias
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2009
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2680237/
https://ncbi.nlm.nih.gov/pubmed/19350118
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