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Catalytic Mechanism and Performance of Computationally Designed Enzymes for Kemp Elimination

A series of enzymes for Kemp elimination of 5-nitrobenzisoxazole have been recently designed and tested. In conjunction with the design process, extensive computational analyses were carried out to evaluate the potential performance of four of the designs, as presented here. The enzyme-catalyzed rea...

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Bibliographic Details
Main Authors: Alexandrova, Anastassia N., Röthlisberger, Daniela, Baker, David, Jorgensen, William L.
Format: Artigo
Language:Inglês
Published: 2008
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2680199/
https://ncbi.nlm.nih.gov/pubmed/18975945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja804040s
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