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Origin of the Activity Drop with the E50D Variant of Catalytic Antibody 34E4 for Kemp Elimination

In enzymes, multiple structural effects cooperatively lead to the high catalytic activity, while individually these effects can be small. The design of artificial enzymes requires the understanding and ability to manipulate such subtle effects. The 34E4 catalytic antibody, catalyzing Kemp eliminatio...

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Bibliografiset tiedot
Päätekijät: Alexandrova, Anastassia N., Jorgensen, William L.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2009
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2702134/
https://ncbi.nlm.nih.gov/pubmed/19132861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jp8076084
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