Preferential Zn(2+) influx through Ca(2+)-permeable AMPA/kainate channels triggers prolonged mitochondrial superoxide production

Synaptically released Zn(2+) can enter and cause injury to postsynaptic neurons. Microfluorimetric studies using the Zn(2+)-sensitive probe, Newport green, examined levels of [Zn(2+)](i) attained in cultured cortical neurons on exposure to N-methyl-d-asparte, kainate, or high K(+) (to activate volta...

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Main Authors: Sensi, Stefano L., Yin, Hong Z., Carriedo, Sean G., Rao, Shyam S., Weiss, John H.
Formato: Artigo
Idioma:Inglês
Publicado: The National Academy of Sciences 1999
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC26798/
https://ncbi.nlm.nih.gov/pubmed/10051656
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