Mutagenesis Is Elevated in Male Germ Cells Obtained from DNA Polymerase-beta Heterozygous Mice

Gametes carry the DNA that will direct the development of the next generation. By compromising genetic integrity, DNA damage and mutagenesis threaten the ability of gametes to fulfill their biological function. DNA repair pathways function in germ cells and serve to ameliorate much DNA damage and pr...

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Autori principali: Allen, Diwi, Herbert, Damon C., McMahan, C. Alex, Rotrekl, Vladimir, Sobol, Robert W., Wilson, Samuel H., Walter, Christi A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Society for the Study of Reproduction, Inc. 2008
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2679517/
https://ncbi.nlm.nih.gov/pubmed/18650495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1095/biolreprod.108.069104
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