Mutagenesis Is Elevated in Male Germ Cells Obtained from DNA Polymerase-beta Heterozygous Mice

Gametes carry the DNA that will direct the development of the next generation. By compromising genetic integrity, DNA damage and mutagenesis threaten the ability of gametes to fulfill their biological function. DNA repair pathways function in germ cells and serve to ameliorate much DNA damage and pr...

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Main Authors: Allen, Diwi, Herbert, Damon C., McMahan, C. Alex, Rotrekl, Vladimir, Sobol, Robert W., Wilson, Samuel H., Walter, Christi A.
Format: Artigo
Sprog:Inglês
Udgivet: Society for the Study of Reproduction, Inc. 2008
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2679517/
https://ncbi.nlm.nih.gov/pubmed/18650495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1095/biolreprod.108.069104
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