Lysine 88 Acetylation Negatively Regulates Ornithine Carbamoyltransferase Activity in Response to Nutrient Signals

Ornithine carbamoyltransferase (OTC) is a key enzyme in the urea cycle to detoxify ammonium produced from amino acid catabolism. OTC deficiency is an X-linked genetic disorder ranging from fatal in newborns to hyperammonemia and anorexia in adults. Through affinity purification of acetylated peptide...

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Bibliographic Details
Main Authors: Yu, Wei, Lin, Yan, Yao, Jun, Huang, Wei, Lei, Qunying, Xiong, Yue, Zhao, Shimin, Guan, Kun-Liang
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2009
Subjects:
Protein Synthesis, Post-Translational Modification, and Degradation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2679468/
https://ncbi.nlm.nih.gov/pubmed/19318352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M901921200
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