Mechanism of Lysine Oxidation in Human Lens Crystallins during Aging and in Diabetes

Oxidative mechanisms during nuclear sclerosis of the lens are poorly understood, in particular metal-catalyzed oxidation. The lysyl oxidation product adipic semialdehyde (allysine, ALL) and its oxidized end-product 2-aminoadipic acid (2-AAA) were determined as a function of age and presence of diabe...

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Détails bibliographiques
Auteurs principaux: Fan, Xingjun, Zhang, Jianye, Theves, Mathilde, Strauch, Christopher, Nemet, Ina, Liu, Xiaoqin, Qian, Juan, Giblin, Frank J., Monnier, Vincent M.
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2009
Sujets:
Protein Synthesis, Post-Translational Modification, and Degradation
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2787324/
https://ncbi.nlm.nih.gov/pubmed/19854833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.032094
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