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Structural characterization of Clostridium acetobutylicum 8-oxoguanine DNA glycosylase in its apo-form and in complex with 8-oxodeoxyguanosine

DNA is subject to a multitude of oxidative damages generated by oxidizing agents from metabolism, from exogenous sources and by ionizing radiation. Guanine is particularly vulnerable to oxidation and the most common oxidative product, 8-oxoguanine (8-oxoG), is the most prevalent lesion observed in D...

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Bibliografiske detaljer
Main Authors: Faucher, Frédérick, Robey-Bond, Susan M., Wallace, Susan S., Doublié, Sylvie
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2678946/
https://ncbi.nlm.nih.gov/pubmed/19361427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2009.01.067
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