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A double transgenic mouse model expressing human pregnane X receptor and cytochrome P450 3A4
Cytochrome P450 3A4 (CYP3A4), the most abundant human P450 in liver, participates in the metabolism of ∼50% of clinically used drugs. The pregnane X receptor (PXR), a member of the nuclear receptor superfamily, is the major activator of CYP3A4 transcription. However, due to species differences in re...
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| Hauptverfasser: | , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2008
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2678901/ https://ncbi.nlm.nih.gov/pubmed/18799805 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.108.022723 |
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