Dehydroalanine analog of glutathione: An electrophilic busulfan metabolite that binds to human glutathione S-transferase A1-1

Elimination of hydrogen sulfide from glutathione (GSH) converts a well-known cellular nucleophile to an electrophilic species, γ-glutamyldehydroalanylglycine (EdAG). We have found that a sulfonium metabolite formed from GSH and busulfan undergoes a facile β-elimination reaction to give EdAG, which i...

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Main Authors: Younis, Islam R., Elliott, Meenal, Peer, Cody J., Cooper, Arthur J.L., Pinto, John T., Konat, Gregory W., Kraszpulski, Michal, Petros, William P., Callery, Patrick S.
Format: Artigo
Sprog:Inglês
Udgivet: 2008
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2678891/
https://ncbi.nlm.nih.gov/pubmed/18791061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.108.142208
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