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Metabolism of the cysteine S-conjugate of busulfan involves a β-lyase reaction

The present work documents the first example of an enzyme-catalyzed β-elimination of a thioether from a sulfonium cysteine S-conjugate. β-(S-Tetrahydrothiophenium)-L-alanine (THT-A) is the cysteine S-conjugate of busulfan. THT-A slowly undergoes a non-enzymatic β-elimination reaction at pH 7.4 and 3...

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Main Authors: Cooper, Arthur J. L., Younis, Islam R., Niatsetskaya, Zoya V., Krasnikov, Boris F., Pinto, John T., Petros, William P., Callery, Patrick S.
Format: Artigo
Jezik:Inglês
Izdano: 2008
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2587289/
https://ncbi.nlm.nih.gov/pubmed/18474673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.108.020768
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