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Metabolism of the cysteine S-conjugate of busulfan involves a β-lyase reaction
The present work documents the first example of an enzyme-catalyzed β-elimination of a thioether from a sulfonium cysteine S-conjugate. β-(S-Tetrahydrothiophenium)-L-alanine (THT-A) is the cysteine S-conjugate of busulfan. THT-A slowly undergoes a non-enzymatic β-elimination reaction at pH 7.4 and 3...
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| Huvudupphovsmän: | , , , , , , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
2008
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2587289/ https://ncbi.nlm.nih.gov/pubmed/18474673 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.108.020768 |
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