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Glutathione Transferase Gene Variants Influence Busulfan Pharmacokinetics and Outcome After Myeloablative Conditioning

BACKGROUND: Busulfan (Bu) and cyclophosphamide (Cy) are frequently included in conditioning regimens before hematopoietic stem cell transplantation (HSCT). Both drugs are detoxified by glutathione transferases (GST), and GST gene variants may explain some of the interindividual variability in pharma...

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Foilsithe in:Ther Drug Monit
Main Authors: Bremer, Sara, Fløisand, Yngvar, Brinch, Lorentz, Gedde-Dahl, Tobias, Bergan, Stein
Formáid: Artigo
Teanga:Inglês
Foilsithe: Therapeutic Drug Monitoring 2015
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4505914/
https://ncbi.nlm.nih.gov/pubmed/25565670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/FTD.0000000000000180
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