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Bile-acid-activated farnesoid X receptor regulates hydrogen sulfide production and hepatic microcirculation

AIM: To investigate whether the farnesoid X receptor (FXR) regulates expression of liver cystathionase (CSE), a gene involved in hydrogen sulfide (H(2)S) generation. METHODS: The regulation of CSE expression in response to FXR ligands was evaluated in HepG2 cells and in wild-type and FXR null mice t...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Renga, Barbara, Mencarelli, Andrea, Migliorati, Marco, Distrutti, Eleonora, Fiorucci, Stefano
Format: Artigo
Sprache:Inglês
Veröffentlicht: The WJG Press and Baishideng 2009
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2678580/
https://ncbi.nlm.nih.gov/pubmed/19418582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3748/wjg.15.2097
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