Obeticholic Acid and Other Farnesoid-X-Receptor (FXR) Agonists in the Treatment of Liver Disorders

The Farnesoid-X-receptor (FXR) is a bile sensor involved in the regulation of bile acid homeostasis, fibrosis, inflammation, and metabolism. Obeticholic acid (OCA), a semisynthetic derivative of chenodeoxycholic acid (CDCA), initially named 6-ethyl-CDCA or INT-747, is the first in a class of FXR lig...

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Hlavní autoři:	Stefano Fiorucci, Ginevra Urbani, Eleonora Distrutti, Michele Biagioli
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	MDPI AG 2025-09-01
Edice:	Pharmaceuticals
Témata:	obeticholic acid (OCA) primary biliary cholangitis (PBC) ursodeoxycholic acid (UDCA) metabolic dysfunction-associated steatohepatitis (MASH) bile acid receptors (BARs)
On-line přístup:	https://www.mdpi.com/1424-8247/18/9/1424
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