Activation of the farnesoid-X receptor protects against gastrointestinal injury caused by non-steroidal anti-inflammatory drugs in mice

BACKGROUND AND PURPOSE: Low doses of acetyl salicylic acid (ASA) and non-steroidal anti-inflammatory drugs (NSAIDs) cause gastrointestinal damage. The farnesoid X receptor (FXR) is a bile acid sensor essential for maintenance of intestinal homeostasis. Here, we have investigated whether FXR is requi...

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Detalhes bibliográficos
Main Authors: Fiorucci, Stefano, Mencarelli, Andrea, Cipriani, Sabrina, Renga, Barbara, Palladino, Giuseppe, Santucci, Luca, Distrutti, Eleonora
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2011
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3246657/
https://ncbi.nlm.nih.gov/pubmed/21564085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2011.01481.x
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