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Botulinum Neurotoxin Serotype A Inhibitors: Small-Molecule Mercaptoacetamide Analogs

Botulinum neurotoxin elicits its paralytic activity through a zinc-dependant metalloprotease that cleaves proteins involved in neurotransmitter release. Currently, no drugs are available to reverse the effects of botulinum intoxication. Herein we report the design of a novel series of mercaptoacetam...

詳細記述

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書誌詳細
主要な著者: Moe, Scott T., Thompson, Andrew B., Smith, Genessa M., Fredenburg, Ross A., Stein, Ross L., Jacobson, Alan R
フォーマット: Artigo
言語:Inglês
出版事項: 2009
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2677997/
https://ncbi.nlm.nih.gov/pubmed/19329331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2009.03.013
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