PROTEINASE ACTIVITY AND RECEPTOR CLEAVAGE: MECHANISM FOR INSULIN RESISTANCE IN SPONTANEOUSLY HYPERTENSIVE RAT

Arterial hypertension is associated with organ dysfunctions, but the mechanisms are uncertain. We hypothesize that enhanced proteolytic activity in the microcirculation of spontaneously hypertensive rats (SHRs) may be a pathophysiological mechanism causing cell membrane receptors cleavage and examin...

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Main Authors: DeLano, Frank A., Schmid-Schönbein, Geert W.
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2677556/
https://ncbi.nlm.nih.gov/pubmed/18606910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/HYPERTENSIONAHA.107.104356
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