Receptor cleavage reduces the fluid shear response in neutrophils of the spontaneously hypertensive rat

Physiological fluid shear stress evokes pseudopod retraction in normal leukocytes by a mechanism that involves the formyl peptide receptor (FPR) as mechanosensor. In hypertensives, such as the spontaneously hypertensive rat (SHR), leukocytes lack the normal fluid shear response. The increased activi...

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Detalhes bibliográficos
Main Authors: Chen, Angela Y., DeLano, Frank A., Valdez, Shakti R., Ha, Jessica N., Shin, Hainsworth Y., Schmid-Schönbein, Geert W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2010
Assuntos:
Vascular Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3006318/
https://ncbi.nlm.nih.gov/pubmed/20861466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00157.2010
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