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Enhanced Matrix Metalloproteinase Activity in the Spontaneously Hypertensive Rat: VEGFR-2 Cleavage, Endothelial Apoptosis, and Capillary Rarefaction

Besides an elevated blood pressure, the spontaneously hypertensive rat (SHR) has multiple microvascular complications including endothelial apoptosis with capillary rarefaction. The SHR also has elevated levels of proteolytic (e.g. matrix metalloproteinase, MMP) activity and apoptosis in microvascul...

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Detalhes bibliográficos
Main Authors: Tran, Edward D., DeLano, Frank A., Schmid-Schönbein, Geert W.
Formato: Artigo
Idioma:Inglês
Publicado em: S. Karger AG 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2968763/
https://ncbi.nlm.nih.gov/pubmed/20145415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000281582
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