Enhanced Matrix Metalloproteinase Activity in the Spontaneously Hypertensive Rat: VEGFR-2 Cleavage, Endothelial Apoptosis, and Capillary Rarefaction

Besides an elevated blood pressure, the spontaneously hypertensive rat (SHR) has multiple microvascular complications including endothelial apoptosis with capillary rarefaction. The SHR also has elevated levels of proteolytic (e.g. matrix metalloproteinase, MMP) activity and apoptosis in microvascul...

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Autors principals: Tran, Edward D., DeLano, Frank A., Schmid-Schönbein, Geert W.
Format: Artigo
Idioma:Inglês
Publicat: S. Karger AG 2010
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2968763/
https://ncbi.nlm.nih.gov/pubmed/20145415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000281582
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