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Probing the Lower Size Limit for Protein-like Fold Stability: Ten-residue Microproteins Greater than 97% Folded in Water at 280K

Mutational optimization of two long-range interactions first observed in Ac-WINGKWT-NH(2) – a) bifurcated H-bonding involving the threonine amide H(N) and sidechain OH and the N-terminal acetyl carbonyl and b) an H-bond between the entgegen-H(N) of the C-terminal amide and the indole ring of Trp6 wh...

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Hlavní autoři: Kier, Brandon L., Andersen, Niels H.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2677142/
https://ncbi.nlm.nih.gov/pubmed/18842046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja804656h
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